Multiple DNA and protein sequence alignment based on segment-to-segment comparison.
نویسندگان
چکیده
منابع مشابه
Multiple DNA and protein sequence alignment based on segment-to-segment comparison
In this paper, a new way to think about, and to construct, pairwise as well as multiple alignments ofDNA and protein sequences is proposed. Rather than forcing alignments to either align single residues or to introduce gaps by defining an alignment as a path running right from the source up to the sink in the associated dot-matrix diagram, we propose to consider alignments as consistent equival...
متن کاملMultiple DNA and protein sequence alignment based on segment-to-segment comparison.
In this paper, a new way to think about, and to construct, pairwise as well as multiple alignments of DNA and protein sequences is proposed. Rather than forcing alignments to either align single residues or to introduce gaps by defining an alignment as a path running right from the source up to the sink in the associated dot-matrix diagram, we propose to consider alignments as consistent equiva...
متن کاملSegment-based multiple sequence alignment
In this PhD thesis the segment-based approach for multiple sequence alignment, initially introduced by the DIALIGN program, is thorougly investigated and substiantially improved. The segment-based approach belongs to the class of local alignment methods and thus is very strong in finding locally conserved motifs, whereas global methods align the input sequences globally from the beginning to en...
متن کاملSegment-based multiple sequence alignment
MOTIVATION Many multiple sequence alignment tools have been developed in the past, progressing either in speed or alignment accuracy. Given the importance and wide-spread use of alignment tools, progress in both categories is a contribution to the community and has driven research in the field so far. RESULTS We introduce a graph-based extension to the consistency-based, progressive alignment...
متن کاملA segment alignment approach to protein comparison
MOTIVATION Local structure segments (LSSs) are small structural units shared by unrelated proteins. They are extensively used in protein structure comparison, and predicted LSSs (PLSSs) are used very successfully in ab initio folding simulations. However, predicted or real LSSs are rarely exploited by protein sequence comparison programs that are based on position-by-position alignments. RESU...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.22.12098